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PDSS2 Inhibits The Ferroptosis Of Vascular Endothelial Cells In Atherosclerosis By Activating Nrf2

Ultimately fatty acid transport, storage, and release in heart, skeletal muscle, and adipose tissues solely depend on PPAR [162]

This gut-derived systemic inflammation drains the body's energetic resources, contributing heavily to the profound, crushing fatigue and cognitive impairment (brain fog) that characterize ME/CFS

Ferritin deficiency-induced Fe 2+ overload consequently promoted ROS-dependent lipid peroxidation, Mtb growth and dissemination, host death via accumulated lipid peroxidation, and ferroptosis of macrophages in Mtb-infected mice (Dow et al., 2021