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Notably, previous studies have confirmed that the aforementioned gut bacteria regulated by dietary fiber (e.g., Bifidobacterium, Lactobacillus, Faecalibacterium ) are closely associated with depression ( 5.3 Potential mechanisms of dietary fiber affecting depression (1) Mood regulation mediated by SCFAs produced via gut microbiota fermentation Dietary fiber cannot be digested and absorbed by the human body but can be partially or fully fermented by gut microbiota (122)