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(42), m/z 145 is formed from BDMC keto form through a hydrogen transfer from benzene ring to C-4 and loss of a neutral moiety, in contrast m/z 119 is produced from BDMC enol form

For each test compound, IC50 values were calculated from dose-response curves established with 10 concentrations of a half-log dilution series

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Improved Insulin Sensitivity For individuals managing type 2 diabetes, tirzepatide has been shown to improve insulin sensitivity