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Description

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Published research protocols most commonly cite doses between 100300mcg/kg body weight per administration for rodent models, administered once daily via subcutaneous injection

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10.1016/j.cmet.2010.02.006 Cell Metab

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HGF/c-Met pathway is one of the most dysregulated pathways in human malignancies, which include, but are not limited to: bladder, breast, cervical, colorectal, endometrial, esophageal, gastric, head and neck, kidney, liver, lung, nasopharyngeal, ovarian, pancreatic, prostate, and thyroid cancers ( Activation of Met in cancer occurs most often through ligand autocrine or paracrine activation

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Suetta C, Frandsen U, Jensen L, Jensen MM, Jespersen JG, Hvid LG, Bayer M, Petersson SJ, Schroder HD, Andersen JL, Heinemeier KM, Aagaard P, Schjerling P, Kjaer M (2012) Aging affects the transcriptional regulation of human skeletal muscle disuse atrophy

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This shift may alter the absorption of many drugs, by for example increasing the ionization of weak acids like aspirin, which reduces their absorption

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