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While most therapies aim to downregulate neutrophils to prevent protease damage, inhaled GM-CSF aims to restore or enhance neutrophil bactericidal function, which may be beneficial for clearing persistent infections like NTM A phase 1 randomized, double-blind, placebo-controlled clinical trial (NCT02468908) involving healthy adults has been completed in the UK

Diclofenac hypersensitivity can cause adverse skin events, such as exfoliative dermatitis, Stevens-Johnson Syndrome (SJS), and toxic epidermal necrolysis (TEN), some of which can be fatal and can occur with or without warning

Free Radical Biol Med (2018) 127:8097

Blood Flow and Angiogenesis : Preclinical findings indicate stimulation of new blood vessel formation, which may improve oxygen and nutrient delivery to damaged tissues

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doi: 10.3390/md22040140