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The present review aimed to explore the dual role of ferroptosis in LC, examining both its pathological and therapeutic implications

Sotorasib (AMG510) first demonstrated efficacy in NSCLC, where the KRAS G12C mutations are found in approximately 13% of cases

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Like all potent biological compounds, IGF-1 LR3 should be approached carefully

By incorporating modifications such as the substitution of Arginine for Glutamic Acid at the third position and extending the peptides N-terminus, IGF-1 LR3 exhibits an enhanced biological activity and a significantly prolonged half-life of approximately 20-30 hours in the human body

Despite the differences in terms of efficacy, no differences have been observed based on the DMT, even in patients being treated with DMF, to whom a special effect of oxidative stress is attributed via activation of the Nrf2 pathway 61