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How Bacterial Metabolites May Influence Mental Wellbeing Elevated levels of the Clostridia metabolite HPHPA (4-hydroxyphenylpropionic acid) have been associated with altered dopamine-to-norepinephrine conversion, as described by Shaw (2010)

Consistent with the approach adopted in the FY 2022 IPPS/LTCH PPS final rule, if a hospital would be trimmed under both the UCC trim methodology and this alternative trim, we will apply this trim in place of the existing UCC trim methodology