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First, 132 mg PVP and 40 mg FeCl 3 6H 2 O were dissolved in 10 mL and 2 mL methanol, respectively

To clarify the causal relationships and stagedependent roles of these factors, we propose a conceptual framework for AD progression (1):Early AD (causal events): Disruption of cerebral iron homeostasis leads to regional iron accumulation, which primes neurons for ferroptosis through elevated ROS and impaired antioxidant defenses (2).Transitional AD (facilitative events): Ferroptotic stress promotes A aggregation and tau hyperphosphorylation

Glutathione plays a central role in immune function and in protecting cells from damage, so maintaining healthy levels remains essential for everyday health

A double-blinded randomized clinical trial with 9 to 14 years follow-up