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Copper deficiency may thus impair the function of these enzymes, leading to an impaired antioxidant defense system and increased susceptibility to oxidative stress [70, 71]

[DOI] [PMC free article] [PubMed] [Google Scholar] 22.Binda D, Vanhoutte EK, Cavaletti G, et al

Nature 612, 347353 (2022)

Ann Rev Biochem 40:345374, 1971

These findings support oxidative stress as a potential mechanistic hub, although a causal relationship has yet to be established

Dual-responsive epigenetic inhibitor nanoprodrug combined with oncolytic virus synergistically boost cancer immunotherapy by igniting gasdermin E-mediated pyroptosis