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Related article: Histamine intolerance genes Mast cell triggers and mediators: Researchers have found that there are a variety of substances within the body that will trigger mast cells to release mediators without complete degranulation

The search terms in PubMed and the Cochrane Library databases included placebo

p 20 drinking days in the past 30 days had higher risk of RTD (HR: 3.07, 95%CI: 1.97, 4.77)

N Engl J Med 372:22682269 Olson RD, Mushlin PS, Brenner DE, Fleischer S, Cusack BJ, Chang BK, Boucek Jr RJ (1988) Doxorubicin cardiotoxicity may be caused by its metabolite, doxorubicinol