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Frequently, however, RCTs are characterized by imperfect compliance, in that not all the subjects who are randomly assigned to take a treatment choose to do so

1 Introduction DKD, characterized by persistent albuminuria and a progressive decline in the glomerular filtration rate among diabetic patients ( The hyperglycemic environment in diabetes triggers glomerular hyperfiltration and tubular epithelial damage ( Current therapeutic approaches for DKD primarily focus on the use of RAAS inhibitors and Sodium-Glucose Cotransporter 2 (SGLT-2) inhibitors, aimed at decelerating glomerular hyperfiltration and diminishing proteinuria ( In summary, the pathogenesis of DKD is complex, with the immune system playing a crucial role in its development

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At the beginning of the experiment, A6 cells were detached with trypsin, and added to 96 well plates at 9 10 3 cells per well

Figure 10 Finally, Spearman correlation analysis was performed to assess the relationships between significantly altered hepatic metabolites and key biological parameters in CUR-treated mice