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Analysis of the PPARGC1A promoter sequence up to 2,000 bp before the transcription initiation site (Genomatix) and sequence comparison between the human and murine PPARGC1A promoter sequence (CLUSTAL O 1.2.0 sequence alignment software) (Supplemental Figure 4A) identified 5 conserved PPREs that span regions 1631/1609 bp, 1386/1362 bp, 1012/991 bp, 634/612 bp, and 210/189 bp (Supplemental Figure 4B)

Mazzocchi A, et al

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No prescription formulations of copper peptide GHK-Cu have received FDA approval for any medical indication, and its use is off-label or investigational in clinical contexts

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Via inhibiting metalloproteinase 1(MMP1) expression, OPs treatment markedly decreased the degradation of collagen and elastin fibers as well as recovered the altered arrangement of extracellular matrix network in the dermis of skin