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However, when a cell is subjected to oxidative stress, Keap 1 is disabled

doi: 10.1111/j.1440-1681.2006.04336.x

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NACETs superior ability to cross the bloodbrain barrier may help protect the brain from damage caused by free radicals (PMC10376274)

Another possibility is that the decline in vulnerability to NMDAR blockade in later development reflects additional antioxidant support supplied by astrocytes, which are still proliferating during this period