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Additionally, oxaliplatin causes inter-strand crosslinks and DNA-protein crosslinks which may contribute to the mode of action of oxaliplatin (Zwelling et al., 1979)

Int J Mol Sci 24(3):1853

Observational studies have demonstrated that concomitant use of opioid analgesics and benzodiazepines increases the risk of drug-related mortality compared to use of opioid analgesics alone