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If you have known allergies or sensitivities to cobalt, vitamin B12 itself, or any additives commonly found in injection solutions, it is important to inform your provider

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IGFBPs can be identified in the human fetal circulation (40), and recently the role of IGFBP-5 in regulating fetal growth was suggested by fetal growth retardation in the absence of a specific IGFBP-5 protease, PPAP-A2 (43)

After that it slowly disappeared because it became more and more difficult to obtain radioactive B12 suitable for human use, and at the same time less and less acceptable to use radioactive B12 in a diagnostic test

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