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One approach involves designing ASOs to induce exon skipping of PTC-containing exons, and removing nonsense mutations from the mature transcript [179,180,181]

A biosimilar is a biologic based on an existing (originator) biologic but is not an exact copy

This can be achieved by using liquid suspensions of crystalline or amorphous materials with poor water solubility

J Biol Chem 274: 2436624371

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Yet, individuals with pre-existing conditions may be at increased risk of serious adverse effects (including death) if one considers the possibility that large doses of supplemental vitamin E might interfere with medications, and possibly lower their efficacy or increase their toxicity (1)