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This method is useful not only for diagnosis but also for tracking disease progression and evaluating the efficacy of iron-targeted therapies

PDMS (Dow Corning Sylgard 184) was mixed in a 10:1 base-to-curing agent ratio and poured over a silicon wafer template consisting of deep etched cylindrical pits with a 200 m diameter, spaced 600 m apart on a square lattice

Flesher JL, Paterson-Coleman EK, Vasudeva P, Ruiz-Vega R, Marshall M, Pearlman E, MacGregor GR, Neumann J and Ganesan AK

Mutant APP and Amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimers disease

10.1016/j.devcel.2017.02.016 Dev