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In line with that, several compounds with NRF2-inducing activity, such as sulforaphane, the anti-epileptic drug dyclonine, DMF, N-acetyl cysteine, and omaveloxolone among others, showed beneficial effects and frataxin-inducing activity in different models of FRDA (Petrillo et al., 2017

Macrophages are frequently observed in various stages of pSS, and their increased presence is linked to more severe tissue damage and higher biopsy lesion scores [116]

If symptoms suggest deficiency but serum B12 looks normal, ask for a methylmalonic acid (MMA) test it detects cellular deficiency earlier

Do not use a vial when sterility is questionable or when its appearance differs from the product instructions, including unexpected cloudiness, particles, precipitation, or color change

For example, ERp57 can be oxidized by ER-protein 72 (ERp72, PDIA4) to promote disulfide bond catalysis (Oka et al., 2015)

A comprehensive evaluation of the individual associations, based on pharmacokinetic studies that also consider individual variability, is still a long way off