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however, in participants undergoing heavy physical stress (e.g., marathon runners, skiers, or soldiers in subarctic conditions), vitamin C supplementation halved the incidence of colds (5 trials)

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While it decreases ROS generation by enhancing antioxidant enzyme activity, DPQ has also been associated with detrimental effects, including increased DNA damage and apoptosis in cardiomyocytes 170

Structure of class B GPCR corticotropin-releasing factor receptor 1