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Oxygen has two unpaired electrons in separate orbitals in its outer shell

[DOI] [PubMed] [Google Scholar] 163.Khera A., Dong L.F., Holland O., Vanderlelie J., Pasdar E.A., Neuzil J., Perkins A.V

Concerning potential DDIs between NRT and anti-TB drugs, DrugBank.com reports that the metabolism of nicotine can be decreased when combined with INH or EMB and increased when co-administered with rifabutin