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Thus, ferroptosis is likely regarded as an effective clinical strategy in order to avoid chemo-resistance in anticancer treatment

Low-dose aspirin therapy for primary prevention of cardiovascular disease: where are we at

We critically appraise this evidence and highlight key translational constraints: very low oral bioavailability and poor intestinal permeability, extensive presystemic biotransformation (microbiome-mediated hydrolysis and CYP-mediated metabolism) with unresolved active species (parent PF versus metabolites), and limited DPN-relevant pharmacokinetics, particularly the lack of peripheral nerve/DRG exposure measurements aligned with pharmacodynamic endpoints

This, however, is not a general rule as synaptic NMDA receptors of dentate gyrus neurons use glycine instead of D-serine as the co-agonist (Le Bail et al., 2015)