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Their low molecular weight and simpler structure enhance diffusion across membranes, enabling oral bioavailability and sometimes crossing the membrane barriers such as blood-brain barrier

For instance, studies on Nrf2 knock-out mouse embryo fibroblasts have shown increased activity of IKK and degradation of IB (138)

These chronic attributes are generally associated with selective degeneration of dopaminergic neurons, corollary de-pigmentation of substantia nigra pars compacta (SNpc) and concomitant accumulation of -synuclein in insoluble inclusions called Lewy bodies 2,3

Lu H, Forbes RA, Verma A

Well, its role cannot be underestimated