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However, impaired glutamate uptake breaks this homeostasis, resulting in neuronal excitotoxicity, changes in synaptic plasticity, dysfunction of astrocytes and microglia, and neurodegeneration [73, 74]

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It can furthermore be expected that the EC 50 values are lower when the target cells express a high number of the target cell surface antigen compared with a low target expression rat

Involving others in assessment adds valuable perspective