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This mechanism reduces endotoxin translocation and inhibits activation of the hepatic TLR4/NF-B inflammatory signaling pathway induced by LPS from Enterobacteriaceae

Chlorpyrifos was previously shown to be resistant to biodegradation and has now been shown to undergo enhanced microbial breakdown to produce less harmful and non-toxic metabolites

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Biotech Histochem 83: 103130 [DOI] [PMC free article] [PubMed] [Google Scholar] Rothenberg SM, Concannon K, Cullen S, Boulay G, Turke AB, Faber AC, Lockerman EL, Rivera MN, Engelman JA, Maheswaran S et al (2015) Inhibition of mutant EGFR in lung cancer cells triggers SOX2FOXO6dependent survival pathways