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Latchoumycandane et al., 2007

Mol Pharmacol 44: 473478

Results Methylcobalamin is a specific and direct inhibitor of GSDME Our previous research found that bile acids as DAMPs can directly engage to trigger pyroptotic cell death of hepatocytes 16,19

doi: 10.1111/imm.12765 112 MariettaEMangalamAKTanejaVMurrayJA

This inflammatory process happens at 3 levels as follows: acute stage (the first hours of incidence of stroke), in which microglia damage the degenerated cells and leukocytes infiltrate, commonly neutrophils