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In the MET4-IO clinical trial, MET4 combined with ICIs demonstrated safety in advanced solid tumors and showed signs of efficacyincluding stable disease in 40% of patientsby reprogramming bile acid metabolism (elevating tauroursodeoxycholic acid) and enhancing CD8 + T cell infiltration (267)

3.3.1 Preclinical evidence Preclinical studies demonstrate that metformin protects against diabetic cardiomyopathy (DCM) through multiple complementary mechanisms (Zhao et al., 2021

Recent studies suggest that traditional non-selective ferroptosis induction strategies need to evolve towards more precise approaches

24 , e55678 (2023)

It was also considered for those who developed progressive hydrocephalus on follow-up imaging without prior EVD

2 ) was also recently cited as a new protector against ROS damage