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A two-stage exacerbated hypoxia nanoengineering strategy induced amplifying activation of tirapazamine for microwave hyperthermia-chemotherapy of breast cancer

The methodology of this study includes establishing an LL37-induced rosacea-like mouse model and observing the therapeutic effects of either combined treatment with minocycline (MIN) and hydroxychloroquine (HCQ) or GBP treatment alone, with the combined MIN and HCQ treatment serving as the positive control

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113 In HD models, enhancing the expression of fusion-promoting proteins like MFN2 and OPA1 through gene therapy or small molecules has shown promise in restoring mitochondrial morphology and improving ATP production