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A combination of PD-1/PD-L1 inhibitors: The prospect of overcoming the weakness of tumor immunotherapy (Review)

Loren Pickart, this peptide complex has an exceptional affinity for copper (II) ions, forming a stable chelate that constitutes one of the main physiological copper transporters in the body

These disruptions prevent Parkin recruitment to damaged mitochondria, inhibit mitochondrial substrate ubiquitination and perturb the PARKIN/PINK1-regulated balance of mitochondrial dynamics, ultimately leading to the accumulation of dysfunctional mitochondria and exacerbated oxidative stress

Curr Opin Biotechnol 37:3644 Liu YJ, Han XM, Ren LL, Yang HL, Zeng QY (2013) Functional divergence of the glutathione S-transferase supergene family in Physcomitrella patens reveals complex patterns of large gene family evolution in land plants

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