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3.2 Chemical instability under physiological and processing conditions Curcumin is notably unstable in both physiological fluids and during standard processing conditions, undergoing rapid degradation that compromises its therapeutic efficacy and shelf stability

The peptide is engineered with a fatty-acid moiety to extend its circulation time (half-life ~6 days), allowing for once-weekly dosing [2]

Similarly, the reduction in EGR1 and FOS suggests a potential mechanism for curbing death receptor signaling and activator protein-1 (AP-1)-mediated inflammation 67,68,69 , While the downregulation of MAP3K8 (TPL2) might modulate the balance between the TGF- -Activated Kinase 1 (TAK1)-NFB and ASK1-c-Jun N-terminal Kinase (JNK) pathways 70

Cancer Lett 266:5359 Niu X, Stancliffe E, Gelman SJ, Wang L et al (2023) Cytosolic and mitochondrial NADPH fluxes are independently regulated

HGH is also known to affect cholesterol levels and, therefore, worsen existing heart conditions

87 , Alnahdi et al