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doi:10.3389/fneur.2019.00875 Ortega MA, Fraile-Martinez O, Garca-Montero C, et al

Mobile phase A was 50 mM ammonium acetate in water, and mobile phase B was acetonitrile

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(Neelakantan et al., 2018) observed that systemic administration of NNMTi to mice with diet-induced obesity markedly attenuated WAT mass and body weight, diminished adipocyte volume, and reduced plasma TC levels

one or more chemical entities e.g., nicotinamide riboside, nicotinamide mononucleotide the invention encompasses contacting one or more NNMT inhibitors (such as a cation of Formula I or IA, or otherwise disclosed herein) is contacted with a cell expressing NNMT concurrently with one or more chemical entities (e.g., nicotinamide riboside, nicotinamide mononucleotide) that modulate intracellular NAD+ levels to provide muscular therapy

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