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Based on previous reports, it is hypothesized that AKT may phosphorylate Keap1, reducing its binding to Nrf2 and thereby enhancing Nrf2 nuclear translocation and the expression of downstream antioxidant genes

However, both substances affect metabolic and oxidative stress pathways, making informed provider guidance essential before starting either therapy

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1 DN is believed to be associated with neuronal, neuroglial cell and vascular endothelial cell injury caused by uncontrolled hyperglycemia, dyslipidemia and IR through multiple pathways, such as ERS, inflammation, oxidative stress and mitochondrial disorders

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These findings highlight the synthetic cumin variety as a promising candidate for sustainable agriculture in water-limited regions, combining drought tolerance with superior agricultural productivity