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2291-C DASATINIB AND QUERCETIN AS SENOLYTICS ATTENUATE FAT DEPOSITION AND HAVE ANTIFIBROTIC EFFECTS IN MEDAKA NONALCOHOLIC STEATOHEPATITIS MODEL Hiroyuki Abe 1 , Shunta Yakubo 1 , Norihiro Sakai 1 , Yusuke Watanabe 1 , Naruhiro Kimura 1 , Toru Setsu 1 , Takeshi Yokoo 1 , Akira Sakamaki 1 , Hiroteru Kamimura 1 , Atsunori Tsuchiya 1 , Kenya Kamimura 2 and Shuji Terai 1 , (1)Graduate School of Medical and Dental Sciences, Niigata University, (2)School of Medicine, Niigata University Background: Non-alcoholic steatohepatitis (NASH) is known to cause cellular senescence due to the effects of oxidative stress, endoplasmic reticulum stress, and autophagy in the liver caused by ectopic fat deposition

And then again, like a grandmother might buy it for her daughter or her granddaughter and this goes down the line

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Protein pellets were further processes to obtain peptides suitable for Mass Spectrometry analysis (see LC-MSMS analysis section)

Their findings underscore the critical role of the lactate/H3K18la/NFB/IL-6 and IL-8 pathways in both aging and AD [76]