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We believe that mGlu5 receptor NAMs or mGlu4 receptor PAMs still cater the potential to behave as broad-spectrum antiparkinsonian agents, combining symptomatic and disease-modifying effects, taking into consideration that studies of neuroprotection in PD await the identification of early biomarkers of the disease, which allow treatments in the presymptomatic stage

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TB-500 (Thymosin Beta-4): Systemic Regeneration Mechanism of Action: TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide in almost all human and animal cells

doi: 10.3390/antiox13111405

The estimated coefficient values along with their p values and fit statistics for the models are given in Supplementary Tables S6 and S7