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Both in vitro and in vivo experiments suggest that Phgdh mRNA is mainly expressed in astrocytes and minimally expressed in neurons (Furuya et al., 2000)

They are typically released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs), including Toll-like receptors (TLRs) and NLRPs (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing, also known as NOD-like receptors)

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Zhang A, et al

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