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Nicotinamide N-methyltransferase: metabolic regulator and emerging therapeutic target (2024 review)

190,191 Inspired by the immunomodulatory properties of defensins, Luo et al

Originally, when our ancestors (think cavemen) were faced with stressful or threatening situations (like being chased by a wild animal), cortisol activated the "fight-or-flight" response to allow them to protect themselves from harm