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Priority research needs include large-scale randomized controlled trials to establish efficacy and safety, dose-ranging studies to optimize treatment protocols, long-term safety studies particularly regarding cancer risk, and comparative effectiveness research with established therapies

Graphic abstract Similar content being viewed by others Introduction Definition of mycochemicals For millennia, mushrooms were well known as a nutritional and pharmaceutical resource especially in traditional oriental therapies, but after the discovery of Penicillin (Fleming 1929), they became a prominent source of natural antibiotics and other bioactive compounds

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Cancer and Metab (2024) 12(1):14