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Rather than observing increasing and persistent JNK activation (persistent pJNK), rising ROS levels, peroxynitrite formation, and release of Endo G and AIF, instead they found pJNK decreased over time to undetectable levels, and hepatic necrosis was prevented ( Figure 22 )

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] (IV;V)), SLR115 ( dvIs67 [ tbb-6p ::GFP+ myo-3p ::dsRed]), SJ4005 ( zcIs4 [ hsp-4 ::GFP] V), SJ4100 ( zcIs13 [ hsp-6 ::GFP]), CF1903 ( glp-1 (e2144) III), GR1373 ( eri-1(mg366) IV ) and MQ1333 ( nuo-6(qm200) I ) strains were obtained from the Caenorhaditis Genetics Center and handled according to standard methods 67

As reported in the previous paragraphs, melatonin is a widespread potent molecule that can reduce cellular damage

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