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Stasis is a major cause of DVT, pulmonary embolism, and post-thrombotic syndrome

Bibliographies were also reviewed to locate additional relevant articles

Emerging biologically informed therapies such as F-652, larsucosterol, and FMT provide encouraging signals but require rigorous, globally harmonised evaluation

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While this decline can be part of normal adaptive aging, it may become clinically relevant when combined with chronic circadian disruption, neurodegenerative processes, metabolic disease, or persistent oxidative and inflammatory stress

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