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Mutations in genes encoding enzymes of the UPS result in renal disease, and mutations in kidney-specific genes result in ubiquitinproteasome dysfunction that leads to renal disease

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The syringe dosing information in this guide applies specifically to compounded tirzepatide from multi-dose vials and self-reconstituted preparations

When these two conditions occur together, it is known as autoimmune polyglandular syndrome type 2 (APS-2)

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