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Previous studies have shown that endothelial glycocalyx (EG) damage is closely associated with the development of S-AKI, and the specific structure and function of the glycocalyx and its role in S-AKI have been studied in recent years (12) (Figure 1)

What We Still Dont Know There are still major gaps in what we know about TB-500 in humans, including long-term safety, effects of repeated use, and impact across different populations over time

For a peptide with unknown human pharmacokinetics, unknown bioavailability, and no human PK/PD data, the resulting number is a starting estimate at best

and the procedure requires at least 2 hours of application on each side

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