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Broad suppression of this process may inadvertently impair the immune systems capacity to mount effective antitumor responses and diminish the overall efficacy of immunotherapy

GLP-1 slows intestinal transit, making dehydration a major risk factor for constipation

T.XuX.et al (2016)

Case in point being valproic acid (aka valproate)

Different strategies influence pro-inflammatory (M1) or anti-inflammatory/reparative (M2) macrophage phenotypes by modulating key metabolic enzymes, nutrient-sensing signals, or metabolite levels, and have shown certain therapeutic potential in a variety of inflammatory or autoimmune disease models