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Synthetic biology techniques, such as gene editing and genetic engineering, can greatly improve biological activity and deliver MOTS-c directly to the acting site, thus further expanding the therapeutic application of MOTS-c

Nausea, vomiting, or diarrhea

At a price, of course, but developing diabetes or hypertension is more expensive in the long run, I guess

The difference comes down to how they work and what they target

Int Med 1992

In clinical trials it produced some of the largest weight-loss and glycemic results of any incretin therapy, with a long half-life that supports a single weekly subcutaneous injection and a stepwise titration that keeps gastrointestinal effects manageable