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As will be appreciated by those in the art, there can be primary target molecules to which the bioactive species binds or acts upon directly and there can be secondary target molecules, which are part of a signalling pathway affected by the bioactive species

Monoclonal Antibody Therapy for GBS The absence of useful additional treatment options is highlighted in patients with GBS of unfavourable prognosis and raises the need for research into more effective therapies

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However, limited information is currently available on the mechanisms leading to secondary resistance

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IAP inhibits LPS-mediated increase in proinflammatory markers in autophagy-dependent manner IAP has been reported to reverse LPS -mediated proinflammatory effects 15,26,32