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Stangel, M., Kuhlmann, T., Matthews, P

Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomised clinical trial

This catalytic role for iron led to the hypothesis that lowering iron availability using iron chelation would protect against ferroptosis in human diseases

By changing the cellular environment and the accessibility of iron, which is essential for macrophage activity, ferroptosis might affect macrophage polarization