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The activation process is complex and continues to be elucidated 9,14,15,16,17

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Within the mitochondria, FDX1 facilitates the reduction and dissociation of the elesclomol-Cu(II) complex, leading to the generation of ROS (240)

Clinical evidence has also emerged: in a cohort of critically ill children, plasma levels of neuronal guidance protein correlated positively with the production of LXA4, MaR1, and PDX, whereas being inversely associated with ICU length of stay and mortality [293]

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