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Diabetic wounds exhibit persistent low-grade chronic inflammation, leading to delayed healing, which may be associated with macrophage dysfunction

Several studies have demonstrated that chronic inflammation leads to several diseases like atherosclerosis, heart disease, Alzheimers disease, asthma, rheumatoid arthritis (RA), acquired immune deficiency syndrome (AIDS), cancer, multiple sclerosis (MS), diabetes, infections (bacteria, fungi, parasites), gout, inflammatory bowel disease (IBD), aging, congestive heart failure (CHF), and other neurodegenerative diseases [3]

229 A retrospective epidemiological study showed that diabetes patients treated with PPAR agonists have a significantly reduced risk of COPD exacerbation, but their risk of cardiovascular risk events has also increased

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