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Description

Electrostatic potential surfaces were computed and visualized with ChimeraX 111 using the coulombic command

However, under hypoxia, PHDs show a decreased activity to catalyze HIF- hydroxylation as available molecular oxygen is not enough, which leads to reduced interaction between HIF- and VHL complex, therefore inhibiting HIF- ubiquitination and promoting HIF accumulation in nucleus (Schdel and Ratcliffe 2019)