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This triggers a cascade of effects: accelerated keratinocyte proliferation, increased desquamation (shedding of the outer layer), and stimulation of collagen synthesis in the dermis

For example, gemcitabine thermosensitive hydrogels or microspheres are used for intraperitoneal perfusion to treat peritoneal metastasis, which can form a drug sustained release reservoir in the peritoneal cavity, prolong local exposure time and reduce systemic toxicity (Xu et al., 2016)

Gastric Extent of Tumor Predicts Peritoneal Metastasis in Siewert II Adenocarcinoma

References Bhattacharya, D

doi: 10.1021/acs.jafc.2c01712

If the benefits of fibrate therapy are indeed mitigated by fibrate-induced betaine deficiency, the use and safety of supplementing patients with betaine would need to be considered (127)