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Monitor patients closely, and perform serum liver testing prior to therapy and at frequent intervals thereafter (5.1) Fetal Risk, particularly neural tube defects, other major malformations, and decreased IQ (5.2, 5.3, 5.4) Pancreatitis, including fatal hemorrhagic cases (5.5) Indications and Usage for Valproic Acid Oral Solution Valproic acid is indicated for: Monotherapy and adjunctive therapy of complex partial seizures

Those results are encouraging for the treatment of HE due to their implications in NH3 metabolism.47 Kidney The kidneys also play an essential role in ammonia homeostasis