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Glutathione synthesis occurs within the liver, the bodys primary detoxification organ

The study of succinate as an oncometabolite has only recently begun, and more research needs to be conducted to completely understand its tumorigenic properties

3.4.1 Interactive crosstalk between airway epithelial cells, fibroblasts, and inflammatory cells Imbalance in pro- and anti-oxidant mechanisms leads to the production of excess ROS, contributing to oxidative stress in the lung

This highlights that different KRAS alleles can create vulnerabilities within the glutamine-glutamate cycle through varied mechanisms, broadening the potential of this therapeutic approach beyond just G12D/V mutants

DOI: 10.1126/science.1360704 31

There seems to be similar bioavailability from vitamin C taken as chewable gummies and tablets and liquids